Chemistry

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For projects involving flow chemistry, pumps that deliver pyrophoric and reactive chemicals in a safe, programmed fashion, with minimal pulsation, across a wide range of flow rates and operating times are necessary. In practice, this means all wetted parts of the system must be inert to a wide range of aggressive matter. > read more

A novel method for assessing the coating uniformity of hot-melt coated particles using micro-computed tomography

The study of Woerthmann et al. presents a new method for analyzing the properties of coated spherical particles, especially the coating layer thickness. The mzr-4605 pump equipped with a heating module was used in their experimental setup for the hot-melt coating experiments to test their novel method and to compare their findings with conventional methods.

B.M. Woerthmann, J.A. Lindner, T. Kovacevic, P. Pergam, F. Schmid, H. Briesen
A novel method for assessing the coating uniformity of hot-melt coated particles using micro-computed tomography
Powder Technology, Volume 378, Part A, 2021, Pages 51-59.
https://doi.org/10.1016/j.powtec.2020.09.065

• Figure

Hydrogen Production from the LOHC Perhydro‐ Dibenzyl‐Toluene and Purification Using a 5 μm PdAg‐Membrane in a Coupled Microstructured System

Alexander Wunsch, Tatjana Berg and Peter Pfeifer of Karlsruher Institut für Technologie (KIT) published about Hydrogen Production from the LOHC Perhydro‐ Dibenzyl‐Toluene and Purification. mzr-2905 was used to pump Perhydro‐ Dibenzyl‐Toluene through a catalyst-membrane reactor.

Alexander Wunsch, Tatjana Berg and Peter Pfeifer
Hydrogen Production from the LOHC Perhydro‐ Dibenzyl‐Toluene and Purification Using a 5 μm PdAg‐Membrane in a Coupled Microstructured System 
Materials 2020, 13, 277
https://www.researchgate.net/publication/338484174

• Figure: Flow diagram of the lab plant for the coupled release and purification of hydrogen

Hot-Melt Extrusion Process Fluctuations and Their Impact on Critical Quality Attributes of Filaments and 3D-Printed Dosage Forms

Quodbach et al. shortly published about continuous manufacturing of API loaden filaments in a twin screw extruder. A micro annular gear pump mzr-7205 was used to feed the plasticizer Triethyl citrate into the extruder.

Hanna Ponsar, Raphael Wiedey, Julian Quodbach
Hot-Melt Extrusion Process Fluctuations and Their Impact on Critical Quality Attributes of Filaments and 3D-Printed Dosage Forms
Pharmaceutics 2020, 12(6), 511
https://doi.org/10.3390/pharmaceutics12060511

• Figure: HME setup for filament production

Use of Lithium Diisopropylamide in Flow: Operability and Safety Challenges Encountered on Multigram Scale

GSK recently published about a lithiation in flow, mzr-6355 of HNPM’s Hermetic inert pump series have been used to feed the process with solutions of LDA and the substrate.

Marta Alonso; Maria Cruz Garcia; Christopher McKay; Lee R. Thorp; Michael Webb; Lee J. Edwards
Use of Lithium Diisopropylamide in Flow: Operability and Safety Challenges Encountered on Multigram Scale
Org. Process Res. Dev. 2021, 25, 4, 988–1000
Publication Date: March 31, 2021
https://doi.org/10.1021/acs.oprd.1c00015

• Figure: Equipment diagram for flow synthesis

Integration of a mzr-pump into a high-tech, modular, fully automatic plant system

Recently, Microinnova integrated a mzr-11558X1, made from Alloy C22 and with double shell, as one of the main components of a highly sophisticated modular plant. > read more

Closed cooling circuit for X-ray Microscope

To investigate aerosol particles in climate simulations the micro annular gear pump mzr-2921 is used in a cooling circuit. The low-pulsation delivery allows precise temperature settings over a wide range. The compact design and low vibration ensure operation without disturbing the sensitive measurements in the X-ray microscope. > read more

Fresh Water and Potable Water System on an Oil Platform

A supplier of offshore equipment designed and manufactured a fresh water and potable water system for one of the most advanced oil platforms.
Micro annular gear pumps of the hermetic inert series in their ATEX versions are used to pump all chemicals for water treatment. > read more

Continuous Manufacturing of Formulations in Minutes instead of Hours

The delivery of small volume flows of difficult, partly highly corrosive liquids is realized with micro annular gear pumps of the Hermetic inert pump series and the High pump performance series. In two compact continuous formulation production plants, eight different liquid feeds with versatile viscosities are mixed for further use. > read more

Multikilogram per Hour Continuous Photochemical Benzylic Brominations Applying a Smart Dimensioning Scale-up Strategy

In 2020 a paper about continuous bromination has been published by Kappe et al. Scale-up to the kg/h has been demonstrated successfully using micro annular gear pumps from HNPM's hermetic inert series.

Alexander Steiner, Philippe M. C. Roth, Franz J. Strauss, Guillaume Gauron, Günter Tekautz, Marc Winter, Jason D. Williams,* and C. Oliver Kappe*
Multikilogram per Hour Continuous Photochemical Benzylic Brominations Applying a Smart Dimensioning Scale-up Strategy
Org. Process Res. Dev. 2020, 24, 2208−2216

• Article: https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00239
• Figure: Piping and instrumentation diagram (PID)

Reaction Calorimetry in continuous flow mode. A new approach for the thermal characterization of high energetic and fast reactions

Novartis Pharma AG, Chemical & Analytical Development, in Basel published about Reaction Calorimetry in continuous flow mode. The micro annular gear pumps mzr-7255 and mzr-7205 have been used to feed reactants into a Fluitec reactor.

Frederik Mortzfeld, Jutta Polenk, Bertrand Guélat, Francesco Venturoni, Berthold Schenkel, and Paolo Filipponi
Reaction Calorimetry in continuous flow mode. A new approach for the thermal characterization of high energetic and fast reactions
Org. Process Res. Dev., Just Accepted Manuscript
DOI: 10.1021/acs.oprd.0c00117 

• Article: http://media.thurne.se/2020/09/Reaction-Calorimetry-in-continuous-flow-mode.pdf
• Figure: Unit for reaction calorimetry in continuous flow mode

APPARATUS FOR DETERMINING COMPRESSIBILITY OF A FLOWING FLUID

There is a fresh patent, US 10,830,681 B2, dated Nov. 10^th 2020, of Endress+Hauser Flowtec AG, Reinach (CH).
A micro annular gear pump (Fig. 2a, 114) is component of an APPARATUS FOR DETERMINING COMPRESSIBILITY OF A FLOWING FLUID.

Patent No.: US 10,830,681 B2
Date of Patent: Nov. 10, 2020
APPARATUS FOR DETERMINING COMPRESSIBILITY OF A FLOWING FLUID
Applicant: Endress+Hauser Flowtec AG, Reinach (CH)
Inventors: Christof Huber, Bern (CH); Michael Lambrigger, Basel (CH)

• U.S. Patent: https://patentimages.storage.googleapis.com/ed/30/4c/7bbb8bb6cfd79b/US10830681.pdf
• Figure: Schematic representation