Chemistry

 

Hot-Melt Extrusion Process Fluctuations and Their Impact on Critical Quality Attributes of Filaments and 3D-Printed Dosage Forms

Quodbach et al. shortly published about continuous manufacturing of API loaden filaments in a twin screw extruder. A micro annular gear pump mzr-7205 was used to feed the plasticizer Triethyl citrate into the extruder.

Hanna Ponsar, Raphael Wiedey, Julian Quodbach
Hot-Melt Extrusion Process Fluctuations and Their Impact on Critical Quality Attributes of Filaments and 3D-Printed Dosage Forms
Pharmaceutics 2020, 12(6), 511
https://doi.org/10.3390/pharmaceutics12060511


Use of Lithium Diisopropylamide in Flow: Operability and Safety Challenges Encountered on Multigram Scale

GSK recently published about a lithiation in flow, mzr-6355 of HNPM’s Hermetic inert pump series have been used to feed the process with solutions of LDA and the substrate.

Marta Alonso; Maria Cruz Garcia; Christopher McKay; Lee R. Thorp; Michael Webb; Lee J. Edwards
Use of Lithium Diisopropylamide in Flow: Operability and Safety Challenges Encountered on Multigram Scale
Org. Process Res. Dev. 2021, 25, 4, 988–1000
Publication Date: March 31, 2021
https://doi.org/10.1021/acs.oprd.1c00015


mzr-11558

Integration of a mzr-pump into a high-tech, modular, fully automatic plant system

Recently, Microinnova integrated a mzr-11558X1, made from Alloy C22 and with double shell, as one of the main components of a highly sophisticated modular plant. > read more


Closed cooling circuit for X-ray Microscope

To investigate aerosol particles in climate simulations the micro annular gear pump mzr-2921 is used in a cooling circuit. The low-pulsation delivery allows precise temperature settings over a wide range. The compact design and low vibration ensure operation without disturbing the sensitive measurements in the X-ray microscope. > read more


Offshore Equipment with mzr-pumps

Fresh Water and Potable Water System on an Oil Platform

A supplier of offshore equipment designed and manufactured a fresh water and potable water system for one of the most advanced oil platforms.
Micro annular gear pumps of the hermetic inert series in their ATEX versions are used to pump all chemicals for water treatment. > read more


Continuous Manufacturing of Formulations in Minutes instead of Hour with mzr-pumps

Continuous Manufacturing of Formulations in Minutes instead of Hours

The delivery of small volume flows of difficult, partly highly corrosive liquids is realized with micro annular gear pumps of the Hermetic inert pump series and the High pump performance series. In two compact continuous formulation production plants, eight different liquid feeds with versatile viscosities are mixed for further use. > read more


Multikilogram per Hour Continuous Photochemical Benzylic Brominations Applying a Smart Dimensioning Scale-up Strategy

In 2020 a paper about continuous bromination has been published by Kappe et al. Scale-up to the kg/h has been demonstrated successfully using micro annular gear pumps from HNPM's hermetic inert series.

Alexander Steiner, Philippe M. C. Roth, Franz J. Strauss, Guillaume Gauron, Günter Tekautz, Marc Winter, Jason D. Williams,* and C. Oliver Kappe*
Multikilogram per Hour Continuous Photochemical Benzylic Brominations Applying a Smart Dimensioning Scale-up Strategy
Org. Process Res. Dev
. 2020, 24, 2208−2216


Rotors mzr-pumps by HNPM

Reaction Calorimetry in continuous flow mode. A new approach for the thermal characterization of high energetic and fast reactions

Novartis Pharma AG, Chemical & Analytical Development, in Basel published about Reaction Calorimetry in continuous flow mode. The micro annular gear pumps mzr-7255 and mzr-7205 have been used to feed reactants into a Fluitec reactor.

Frederik Mortzfeld, Jutta Polenk, Bertrand Guélat, Francesco Venturoni, Berthold Schenkel, and Paolo Filipponi
Reaction Calorimetry in continuous flow mode. A new approach for the thermal characterization of high energetic and fast reactions
Org. Process Res. Dev., Just Accepted Manuscript
DOI: 10.1021/acs.oprd.0c00117 


APPARATUS FOR DETERMINING COMPRESSIBILITY OF A FLOWING FLUID

There is a fresh patent, US 10,830,681 B2, dated Nov. 10th 2020, of Endress+Hauser Flowtec AG, Reinach (CH).
A micro annular gear pump (Fig. 2a, 114) is component of an APPARATUS FOR DETERMINING COMPRESSIBILITY OF A FLOWING FLUID.

Patent No.: US 10,830,681 B2
Date of Patent: Nov. 10, 2020
APPARATUS FOR DETERMINING COMPRESSIBILITY OF A FLOWING FLUID
Applicant: Endress+Hauser Flowtec AG, Reinach (CH)
Inventors: Christof Huber, Bern (CH); Michael Lambrigger, Basel (CH)


 

Other applications in chemistry

  • Fine chemicals / Pharmaceutical industry
  • Flow Chemistry
  • Coating applications
  • Organic electronics
  • Mini plant technology
  • Polymer development
  • Dosing of additives into extruders
  • Filling of radioactive isotope solutions
  • Dosage of sodium

 

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