Precision dosing in modular flow chemistry systems at kilo lab scale
In flow chemistry, the combination of precise dosing and pressure stability is essential for maintaining constant reaction conditions. HNP Mikrosysteme’s micro annular gear pumps reliably provide this level of process stability - even at high operating pressures. (Dr. Dirk Kirschneck, Strategic Director, Microinnova Engineering GmbH)
Constant reaction conditions through high-precision dosing (CV < 1%) at pressures up to 80 bar
Continuous processes are increasingly being implemented at kilo lab scale for fine chemical production and process development. Systems such as the FlowKiloLab® from Microinnova Engineering GmbH enable flexible scale-up of chemical processes.
One of the key challenges is maintaining constant reaction conditions. Even minor fluctuations in flow rate or pressure can affect product quality.
The FlowKiloLab® is based on modular Module Type Package (MTP) units. This open architecture enables rapid integration and exchange of individual modules, supports plug-and-produce concepts, and facilitates scale-up to larger production systems, such as the FlowTonPlant®.
What are the dosing requirements in flow chemistry systems?
Stable continuous processes at kilo lab scale require:
- highly precise and reproducible flow rates (CV < 1%)
- extremely low-pulsation liquid delivery for constant reaction conditions
- reliable dosing at elevated system pressures (up to 80 bar)
- a wide flow rate range (0.048–288 ml/min)
- high system availability during continuous operation
- flexible integration into modular process systems
In practice, not all pump technologies provide the required combination of pressure stability and dosing precision. Micro annular gear pumps deliver both highly accurate dosing and stable performance under pressure.
How is dosing implemented in the FlowKiloLab®?
For applications requiring high pressure capability, dosing accuracy, and minimal pulsation, the mzr-7255 micro annular gear pump is used.
It provides extremely low-pulsation, reproducible flow over a wide operating range, supporting stable reaction conditions throughout the production process.
Its compact design and low internal volume contribute to stable system operation, which is particularly important for continuous reactions involving sensitive process parameters.
What are the benefits for modular process systems?
By integrating the micro annular gear pump, the process system can:
- maintain stable and reproducible reaction conditions
- provide extremely low-pulsation flow for continuous processes
- dose accurately even at elevated pressures
- maintain consistent product quality
- maximize system availability during continuous operation
- configure, expand, and scale modular process systems
This fluid handling solution enables precise and pressure-stable dosing for modular flow chemistry systems. It supports plug-and-produce concepts, facilitates the scale-up of modular process systems, and provides the foundation for reproducible continuous processes.